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In rats, anabolic steroids also act in the peripheral metabolism of thyroid hormones and seem to exert an important proliferative effect on thyroid cells, , which is considered as the molecular mechanism of their activity. This effect may be due to inhibition of aromatization of thyroid hormones in the luteal phase, as described by Tzourio-Mazoyer, et al.  and in women , , ,  as well as by inhibition of aromatization of testosterone in women . The present experiments demonstrate that testosterone, but not cortisol, can induce a large weight gain of obese females. This effect is associated with the increase of fat mass. Another mechanism by which androgens exert their potent influence on thyroid gland function through the increase of thyroid stimulating hormone secretion is by the activation of the nuclear factor of activated T-cell receptors (NfAT), also known as nuclear transcription factor-1a . The activation of NfAT is linked to the stimulation of the production of TSH in order to stimulate T3 activity. On the other hand the presence of the Nf gene in obese females is associated with lower levels of T3 due to a decrease of the ratio of the active T to inactive T3 . In our previous studies, we observed that cortisol causes a reduction in body weight due to the increase of thyroid stimulating hormone secretion , because our previous studies showed that cortisol is a critical hormone in the regulation of body weight (also see  for an analysis). Our results confirm that cortisol stimulates thyroid stimulating hormone secretion in obese females and increase its secretion with increasing cortisol concentration ( ). We measured the levels of thyroid stimulating hormone secretion by the use of radioimmunoassay kits, using an iodide-labeled immunophenol (IP), from female rats. Thyroid stimulating hormone secretion was calculated as calculated from the results of the immunosupressurization and was compared between the groups treated with cortisol and with the control group . An elevated level of thyroid stimulating hormone was observed especially when there was a large weight gain, in a model that was similar to what was observed in our previous studies that were based on the combination of fat mass and body weight in obese females ,  and when body weight was controlled . However, there were no statistically significant differences in the total body fat or the mean body weight at the end of the 10-week treatment period between the two groups. Thus, the increased plasma androgen concentrations are most likely the only major factor responsible for the Similar articles: